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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are often characterized by their focus on practical aspects of designing a study which include recruitment and consent, adherence and the use of routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and included participants from different geographic areas. This kind of heterogeneity is required for pragmatic trials to be valid, and it also helps to reduce bias in the results. A high degree of heterogeneity, however can result in problems with the trial design.

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The purpose of pragmatic trials is to simulate real-life scenarios and to achieve the highest level of validity externally. They are usually requested by policy makers and 프라그마틱 정품 사이트 - mouse click the up coming website page - practitioners to guide their decision-making. They can also be used to assess the cause-effect relationship of an intervention and its results. However, they shouldn't be used in lieu for explanation trials.

The idea of pragmatism is controversial, and there are questions about whether pragmatic trials can replace tests for explanations or if they should be an addition to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which validate a physiological or clinical hypothesis and pragmatic trials, which guide the policy and practice of. They also proposed an approach to pragmatic trials, called PRECIS.2 This tool sought to define the characteristics of a pragmatic study, including the recruitment process, the design and implementation of the intervention, and 프라그마틱 순위 [Highly recommended Online site] monitoring.

There is a positive trend in the number of pragmatic trials that have been published. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This is an indication that the health science community is becoming increasingly sensitized to the issue of pragmatics. It is important to remember that the majority of these trials were conducted in primary care settings.